反应详情

温度

70 °C

0.77 g (4.00 mmol) 2-(methoxymethyl)-4-methyl-1H-benzo[d]imidazol-6-ol and 0.68 g (4.40 mmol) 4,6-dichloropyrimidine in 5.0 mL DMF were combined with 1.66 g (12.0 mmol) potassium carbonate and stirred for 8 h at 70° C. Then ice water was added and the substance was extracted with ethyl acetate and concentrated by rotary evaporation i.vac. The residue was purified by preparative HPLC-MS. The fractions containing product were combined and evaporated down i.vac.

1. extractionthe substance was extracted with ethyl acetate
2. concentrationconcentrated by rotary evaporation i.vac
3. customThe residue was purified by preparative HPLC-MS
4. additionThe fractions containing product
5. customevaporated down i.vac