Hydrochloric Acid → 1231750-12-1

HRID 1846486Notes

Reaction equation

HRID 1846486 reaction equation
[NH2:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([OH:9])=[CH:4][C:3]=1[OH:10].C(=O)([O-])[O-].[K+].[K+].Br[CH2:18][C:19](Cl)=[O:20].Cl>C(#N)C.O>[OH:9][C:5]1[CH:6]=[C:7]([CH3:8])[C:2]2[NH:1][C:19](=[O:20])[CH2:18][O:10][C:3]=2[CH:4]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 89602Bromoacetyl chlorideHCID 552817384-Amino-5-methylbenzene-1,3-diol

Product 1

HCID 669780401231750-12-1

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6342AcetonitrileSolvent

Conditions

Temperature
70 °C

Procedure

1.0 g (7.2 mmol) 4-amino-5-methylbenzene-1,3-diol and 2.2 g (15.8 mmol) potassium carbonate in 20.0 mL acetonitrile were cooled in the ice bath. 0.65 mL (7.9 mmol) bromoacetyl chloride were added dropwise and the reaction mixture was stirred for 30 min at RT and for 1 h at 70° C. The mixture was combined with water, acidified with aqueous hydrochloric acid and extracted with dichloromethane. The organic phase was separated off, dried and evaporated down i.vac.

Workup

  1. extractionextracted with dichloromethane
  2. customThe organic phase was separated off
  3. customdried
  4. customevaporated down i.vac

Sources & evidence

ORD record
ord-c06976d5c2114237a088b2e8c91f22a8
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

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