Water → HCID 66978307, compound

HRID 1846563Notes

Reaction equation

HRID 1846563 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[NH:12][C:11](=[O:13])[N:10]([CH:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[CH2:9][CH2:8][C:7]=2[CH:20]=1.[Cl:21][C:22]1[C:30]2[N:29]=[C:28]([CH3:31])[NH:27][C:26]=2[CH:25]=[CH:24][C:23]=1[O:32][C:33]1[CH:38]=[C:37](Cl)[N:36]=[CH:35][N:34]=1.CCN(C(C)C)C(C)C.O>CN(C=O)C>[Cl:21][C:22]1[C:30]2[N:29]=[C:28]([CH3:31])[NH:27][C:26]=2[CH:25]=[CH:24][C:23]=1[O:32][C:33]1[N:34]=[CH:35][N:36]=[C:37]([N:17]2[CH2:18][CH2:19][CH:14]([N:10]3[CH2:9][CH2:8][C:7]4[CH:20]=[C:3]([O:2][CH3:1])[CH:4]=[CH:5][C:6]=4[NH:12][C:11]3=[O:13])[CH2:15][CH2:16]2)[CH:38]=1

Participants

6

Reactant 4

HCID 962WaterHCID 81531DiisopropylethylamineHCID 183568527-methoxy-3-(piperidin-4-yl)-4,5-dihydro-1H-benzo[d][1,3]diazepin-2(3H)-oneHCID 86663919HCID 86663919, compound

Product 1

HCID 66978307HCID 66978307, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

100 mg (0.36 mmol) 7-methoxy-3-piperidin-4-yl-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one, 110 mg (0.37 mmol) 4-chloro-5-(6-chloropyrimidin-4-yloxy)-2-methyl-1H-benzo[d]-imidazole and 0.14 mL (0.81 mmol) DIPEA in 2.0 mL DMF were stirred for 3 h at RT and for 4 h at 40° C. The reaction mixture was mixed with water. The precipitate formed was suction filtered, washed and dried. The filtrate was again suction filtered, washed and dried.

Workup

  1. customThe precipitate formed
  2. filtrationfiltered
  3. washwashed
  4. customdried
  5. filtrationfiltered
  6. washwashed
  7. customdried

Sources & evidence

ORD record
ord-ff52105de00747948fe720e7fa4264b6
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

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