反应详情

温度

50 °C

HCl (5-6 N in IPA, 3 mL) was added to a solution of tert-butyl 3-(benzyloxy)cyclobutylcarbamate (1.07 g, 3.86 mmol) in THF (10 mL). The mixture was stirred at 50° C. for 3 h, then cooled to RT. The solvent was removed in vacuo and EtOAc (10 mL) was added. The resulting suspension was cooled to 0° C. for 1 h, then the solid was collected by filtration to give the amine as a white solid (601 mg, 73%).

1. temperaturecooled to RT
2. customThe solvent was removed in vacuo and EtOAc (10 mL)
3. additionwas added
4. temperatureThe resulting suspension was cooled to 0° C. for 1 h
5. filtrationthe solid was collected by filtration