HCID 58548537, compound → HCID 58548620, compound

HRID 1846779Notes

Reaction equation

HRID 1846779 reaction equation
C[O:2][CH:3]1[CH2:8][CH2:7][CH:6]([C:9]2[S:10][C:11]3[CH:17]=[CH:16][CH:15]=[CH:14][C:12]=3[N:13]=2)[CH2:5][CH2:4]1>I.O>[S:10]1[C:11]2[CH:17]=[CH:16][CH:15]=[CH:14][C:12]=2[N:13]=[C:9]1[CH:6]1[CH2:7][CH2:8][CH:3]([OH:2])[CH2:4][CH2:5]1

Participants

4

Reactant 1

HCID 58548537HCID 58548537, compound

Product 1

HCID 58548620HCID 58548620, compoundYield 85%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 24841Hydrogen iodideSolvent

Procedure

A solution of 2-(4-methoxy-cyclohexyl)-benzothiazole (1.2 g, 5.15 mmol) in HI (35%)(12 mL) was heated to 90° C. for 1 h. Then the reaction mixture was diluted with water (20 mL), extracted with EtOAc (2×) and the separated organic layer was washed with brine (2×), dried over Na2SO4, and concentrated to give the desired product (960 mg, 4.12 mmol, 85% yield) as brown solid.

Workup

  1. extractionextracted with EtOAc (2×)
  2. washthe separated organic layer was washed with brine (2×)
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-b1f9ba65db484778be72c9d97c581fe0
Source dataset
uspto-grants-2015_02
Patent number
US08952037B2

Reaction notes

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