反应详情

温度

150 °C

In a 5 mL vial 6-bromo-[1,2,4]triazolo[4,3-a]pyridine (93 mg), 4-trifluoromethoxyphenylboronic acid (115 mg), and potassium carbonate (187 mg) were suspended in DMF (2 mL) that was previously degassed with nitrogen. Tetrakis(triphenylphosphine) palladium (20 mg) was added and the reaction mixture was heated in a microwave reactor at 150° C. for 30 min, filtered, and concentrated. The residue was subjected to gradient chromatography (MeOH/dichloromethane) to produce white powder, 56.4 mg (43% yield).

1. customwas previously degassed with nitrogen
2. additionTetrakis(triphenylphosphine) palladium (20 mg) was added
3. filtrationfiltered
4. concentrationconcentrated
5. customto produce white powder, 56.4 mg (43% yield)