反应详情

To a microwave reaction tube was added 6-chloro-3-isopropyl-[1,2,4]triazolo[4,3-b]pyridazine prepared as described in Step 1 above (1.28 mmole), 2-methyl-4-(trifluoromethoxy)phenylboronic acid (1.40 mmole), tetrakis(triphenylphosphine)palladium (0.064 mmole), 2M Na2CO3 (1 mL), and DMF (3 mL). The resulting reaction mixture was heated in the microwave at 130 C for 10 min. The reaction mixture was diluted with ethyl acetate and filtered through celite. The filtrate was washed with water. The organic extract was dried over Na2SO4 and evaporated in vacuo. The crude residue was purified by preparative HPLC to afford 3-isopropyl-6-(2-methyl-4-(trifluoromethoxy)phenyl)-[1,2,4]triazolo[4,3-b]pyridazine.

1. customTo a microwave reaction tube
2. customprepared
3. customThe resulting reaction mixture
4. temperaturewas heated in the microwave at 130 C for 10 min
5. filtrationfiltered through celite
6. washThe filtrate was washed with water
7. extractionThe organic extract
8. dry with materialwas dried over Na2SO4
9. customevaporated in vacuo
10. customThe crude residue was purified by preparative HPLC