Triethylamine → HCID 565655, compound

HRID 1846988Notes

Reaction equation

HRID 1846988 reaction equation
[CH2:1]([NH2:10])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][NH2:9].C(N([CH2:16][CH3:17])CC)C.[O:18]1[CH:22]=[CH:21][CH:20]=[C:19]1[C:23](Cl)=[O:24]>CN(C1C=CN=CC=1)C>[CH2:1]([NH:10][C:23]([C:19]1[O:18][CH:22]=[CH:16][CH:17]=1)=[O:24])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][NH:9][C:23]([C:19]1[O:18][CH:22]=[CH:21][CH:20]=1)=[O:24]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 242501,8-OctanediamineHCID 682422-Furancarbonyl chloride

Product 1

HCID 565655HCID 565655, compound

Reagents, catalysts & solvents 1

HCID 142844-(Dimethylamino)pyridineCatalyst

Procedure

The general procedure was carried out using 1,8-octanediamine (10.0 g, 69.3 mmol), triethylamine (14.2 g, 141 mmol), DMAP (0.17 g, 1.35 mmol) and furoyl chloride (19.0 g, 146 mmol). The resulting compound was purified by column chromatography (98:2 DCM:EtOAc), and the product obtained as a white solid (21.5 g/92%).

Workup

  1. customThe resulting compound was purified by column chromatography (98:2 DCM:EtOAc)
  2. customthe product obtained as a white solid (21.5 g/92%)

Sources & evidence

ORD record
ord-b6ca8042b99742a19022ba391202119a
Source dataset
uspto-grants-2015_02
Patent number
US08952094B2

Reaction notes

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