Hydrochloric Acid → 3-(7-Fluoro-2-oxoquinoxalin-1(2H)-yl)propanal

HRID 1847089Notes

Reaction equation

HRID 1847089 reaction equation
[O:1]1CCO[CH:2]1[CH2:6][CH2:7][N:8]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([F:18])[CH:16]=2)[N:11]=[CH:10][C:9]1=[O:19].Cl.C(=O)([O-])O.[Na+]>O1CCOCC1>[F:18][C:15]1[CH:16]=[C:17]2[C:12]([N:11]=[CH:10][C:9](=[O:19])[N:8]2[CH2:7][CH2:6][CH:2]=[O:1])=[CH:13][CH:14]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 86725012HCID 86725012, compound

Product 1

HCID 867250133-(7-Fluoro-2-oxoquinoxalin-1(2H)-yl)propanal

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of 1-[2-(1,3-dioxolan-2-yl)ethyl]-7-fluoroquinoxalin-2(1H)-one (0.6 g, 2.3 mmol) in 1,4-dioxane (6.8 ml) was added 4N hydrochloric acid (24 ml) and the mixture was stirred at room temperature for 5 hours. An aqueous solution of sodium hydrogen carbonate was added thereto and then the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate, concentrated under reduced pressure and dried under vacuum. 0.6 g (quantitative).

Workup

  1. extractionthe mixture was extracted with ethyl acetate
  2. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  3. concentrationconcentrated under reduced pressure
  4. customdried under vacuum

Sources & evidence

ORD record
ord-439251c57e614dbbaadf71385e554a48
Source dataset
uspto-grants-2015_02
Patent number
US08952010B2

Reaction notes

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