HCID 68008633, compound → HCID 68008765, compound

HRID 1847119Notes

Reaction equation

HRID 1847119 reaction equation
[CH2:1]([O:4][CH2:5][C@H:6]([C@@H:8]1[C@@:12]2([CH3:31])[CH2:13][CH2:14][C:15]3[C@@:16]4([CH3:30])[CH2:25][CH2:24][C@H:23]([O:26][CH2:27][O:28][CH3:29])[CH2:22][C@@H:17]4[C:18](=[O:21])[O:19][C:20]=3[C@@H:11]2[CH2:10][CH2:9]1)[CH3:7])[CH:2]=[CH2:3]>C(OCC)(=O)C.[C].[Pd]>[CH3:29][O:28][CH2:27][O:26][C@@H:23]1[CH2:22][C@@H:17]2[C:18](=[O:21])[O:19][C:20]3[C@@H:11]4[CH2:10][CH2:9][C@H:8]([C@H:6]([CH3:7])[CH2:5][O:4][CH2:1][CH2:2][CH3:3])[C@@:12]4([CH3:31])[CH2:13][CH2:14][C:15]=3[C@@:16]2([CH3:30])[CH2:25][CH2:24]1

Participants

4

Reactant 1

HCID 68008633HCID 68008633, compound

Product 1

HCID 68008765HCID 68008765, compoundYield 76%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8857Ethyl AcetateSolvent

Procedure

Compound 66 (3.7 mg, 0.0086 mmol) obtained in Example 68 was dissolved in ethyl acetate (2 mL), and 10% palladium-carbon (2.0 mg) was added thereto, followed by stirring at room temperature for 2 hours under a hydrgen atmosphere. The catalyst was sparated by filtration, followed by concentrating the filtrate to obtain the title compound (2.8 mg, 76%).

Workup

  1. filtrationThe catalyst was sparated by filtration
  2. concentrationby concentrating the filtrate

Sources & evidence

ORD record
ord-f4008da15c9348799540003b382080bb
Source dataset
uspto-grants-2015_02
Patent number
US08952003B2

Reaction notes

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