反应详情

温度

80 °C

Compound 56 (110 mg, 0.250 mmol) in obtained in Example 46 was dissolved in tert-butanol (5 mL), and pyrimidium p-toluenesulfonate (1.9 g; 7.4 mmol) was added thereto, followed by stirring at 80° C. for 1 hour. A saturated aqueous sodium bicarbonate solution was added to the reaction mixture, followed by extraction with ethyl acetate twice. The organic layer was dried over anhydrous sodium sulfate, and concentrated under reduced pressure to yield a residue. The residue was purified by column chromatography to obtain the title compound (84 mg, 85%).

1. extractionfollowed by extraction with ethyl acetate twice
2. dry with materialThe organic layer was dried over anhydrous sodium sulfate
3. concentrationconcentrated under reduced pressure
4. customto yield a residue
5. customThe residue was purified by column chromatography