Ethyl Acetate → HCID 66643942, compound

To a solution of 5-bromo-2-benzofuran-1(3H)-one (5.00 g, 23.5 mmol) at 0° C. in TfOH (100 mL) was added NIS (5.55 g, 24.6 mmol). The mixture was stirred at room temperature over night; LC analysis of the reaction mixture indicated completion of the reaction. The reaction mixture was then poured slowly into ice-water (1 L) with stirring. To the solution was then added EtOAc (500 mL) and subsequently stirred for 10 min. The mixture was filtered and the organic layer separated. The aqueous layer was extracted with EtOAc (2×200 mL). The combined organic layers were washed with water (500 mL), brine (500 mL), dried over Na2SO4, filtered, and concentrated to dryness; the resulting material was absorbed onto silica gel and separated with the solvent system of (hexanes/EtOAc=1/1) to yield 5-bromo-4-iodo-2-benzofuran-1 (3H]-one.

1. customcompletion of the reaction
2. stirringwith stirring
3. filtrationThe mixture was filtered
4. customthe organic layer separated
5. extractionThe aqueous layer was extracted with EtOAc (2×200 mL)
6. washThe combined organic layers were washed with water (500 mL), brine (500 mL)
7. dry with materialdried over Na2SO4
8. filtrationfiltered
9. concentrationconcentrated to dryness
10. customthe resulting material was absorbed onto silica gel
11. customseparated with the solvent system of (hexanes/EtOAc=1/1)

ORD record

ord-20bae14cd60044c0a078bb433e0c0610

Source dataset

uspto-grants-2015_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08952166B2