反应详情

温度

60 °C

(6-Hydroxy-1-benzofuran-3-yl)acetic acid (25.00 g) and (S)-2-amino-1,1-diphenylpropan-1-ol (29.57 g) were added to ethyl acetate (175 mL), and the mixture was dissolved by stirring at 60° C. After allowing to cool to room temperature, isopropyl ether (200 mL) was added, and the mixture was stirred for 1 hr. The solid was collected by filtration, and washed with a mixed solvent (1:1, 100 mL) of ethyl acetate-isopropyl ether. The solid was dried under reduced pressure at 50° C. to give the title compound (53.81 g).

1. dissolutionthe mixture was dissolved
2. temperatureto cool to room temperature
3. stirringthe mixture was stirred for 1 hr
4. filtrationThe solid was collected by filtration
5. washwashed with a mixed solvent (1:1, 100 mL) of ethyl acetate-isopropyl ether
6. customThe solid was dried under reduced pressure at 50° C.