Allyl bromide → HCID 68666849, compound

HRID 1848847Notes

Reaction equation

HRID 1848847 reaction equation
Cl.[N+:2]([C:5]1[CH:6]=[C:7]([S:18]([NH2:21])(=[O:20])=[O:19])[CH:8]=[CH:9][C:10]=1[NH:11][CH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1)([O-:4])=[O:3].C(N(CC)CC)C.Br[CH2:30][CH:31]=[CH2:32]>CN(C)C=O>[CH2:32]([N:15]1[CH2:16][CH2:17][CH:12]([NH:11][C:10]2[CH:9]=[CH:8][C:7]([S:18]([NH2:21])(=[O:19])=[O:20])=[CH:6][C:5]=2[N+:2]([O-:4])=[O:3])[CH2:13][CH2:14]1)[CH:31]=[CH2:30]

Participants

5

Reactant 3

HCID 7841Allyl bromideHCID 8471TriethylamineHCID 67170227HCID 67170227, compound

Product 1

HCID 68666849HCID 68666849, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

3-nitro-4-(piperidin-4-ylamino)benzenesulfonamide hydrochloride (0.27 g), triethylamine (0.2 mL) and 3-bromoprop-1-ene (0.1 g) was dissolved in N,N-dimethylformamide (5 mL). The mixture was stirred at room temperature overnight. The solvent was dried under vacuum. The mixture was chromatographed on silica gel with 0-20% methanol in dichloromethane.

Workup

  1. customThe solvent was dried under vacuum
  2. customThe mixture was chromatographed on silica gel with 0-20% methanol in dichloromethane

Sources & evidence

ORD record
ord-18b6b8b783bd460d88fcb95e77f7e7b6
Source dataset
uspto-grants-2015_02
Patent number
US08952157B2

Reaction notes

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