反应详情

To a solution of 2-chloro-3-fluorophenylboronic acid (5.0 g) in tetrahydrofuran (50 mL) and 1M aqueous NaOH (30 mL) at 0° C. was added 30% hydrogen peroxide solution (4 mL), and the reaction was stirred for 2 hours. The reaction was quenched with saturated aqueous Na2S2O3 solution, acidified with concentrated aqueous HCl, and extracted twice with ethyl acetate. The combined extracts were washed with brine, concentrated, and chromatographed on silica gel using 10% ethyl acetate/hexanes as eluent to give the product.

1. customThe reaction was quenched with saturated aqueous Na2S2O3 solution
2. extractionextracted twice with ethyl acetate
3. washThe combined extracts were washed with brine
4. concentrationconcentrated
5. customchromatographed on silica gel using 10% ethyl acetate/hexanes as eluent
6. customto give the product