反应详情

温度

50 °C

To a solution of EXAMPLE 368D (250 mg) in anhydrous N,N-dimethylformamide (6 mL) was added sodium hydride (34.1 mg). The mixture was stirred at 50° C. for 30 minutes. Then, iodomethane (35.6 μl) was added and the mixture was stirred at 50° C. overnight. The reaction mixture was quenched with water (30 mL), then extracted with ethyl acetate. The solution was dried (MgSO4), filtered and concentrated to give the title compound.

1. stirringthe mixture was stirred at 50° C. overnight
2. customThe reaction mixture was quenched with water (30 mL)
3. extractionextracted with ethyl acetate
4. dry with materialThe solution was dried (MgSO4)
5. filtrationfiltered
6. concentrationconcentrated