反应详情

To a solution of (5-fluoro-2-methyl-indol-1-yl)-acetic acid (0.5 g) and biphenyl-4-thiol (0.19 g) in DMF (5 ml) was added iodine (0.25 g). After stirring at RT overnight the mixture was poured into water, the pH adjusted to 3 using 1M HCl and the organics extracted with EtOAc. The EtOAc extractions were combined, washed with brine, dried (MgSO4) and evaporated under reduced pressure to give crude material. Purification using RPHPLC gave the title compound as a pink solid (0.1 μg).

1. extractionthe organics extracted with EtOAc
2. extractionThe EtOAc extractions
3. washwashed with brine
4. dry with materialdried (MgSO4)
5. customevaporated under reduced pressure
6. customto give crude material
7. customPurification