HCID 86703773, compound → HCID 86703774, compound

HRID 1849896Notes

Reaction equation

HRID 1849896 reaction equation
[CH:1]([N:14]1[CH2:17][CH:16]([O:18][C:19]2[C:31]([CH:32]3[CH2:34][CH2:33]3)=[CH:30][C:22]([C:23]([O:25]C(C)(C)C)=[O:24])=[C:21]([F:35])[CH:20]=2)[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(Cl)Cl.FC(F)(F)C(O)=O>[CH:1]([N:14]1[CH2:15][CH:16]([O:18][C:19]2[C:31]([CH:32]3[CH2:33][CH2:34]3)=[CH:30][C:22]([C:23]([OH:25])=[O:24])=[C:21]([F:35])[CH:20]=2)[CH2:17]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 86703773HCID 86703773, compound

Product 1

HCID 86703774HCID 86703774, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of tert-butyl 4-(1-benzhydrylazetidin-3-yloxy)-5-cyclopropyl-2-fluorobenzoate (650 mg, 1.37 mmol) in DCM (10 mL) and trifluoroacetic acid (5 mL) was stirred at room temperature for 2 h. The solvent was removed and the residue was used in the next step without further purification.

Workup

  1. customThe solvent was removed
  2. customthe residue was used in the next step without further purification

Sources & evidence

ORD record
ord-256d3e420ce244a492e47ee142c42dba
Source dataset
uspto-grants-2015_02
Patent number
US08952169B2

Reaction notes

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