HCID 86703792, compound → HCID 86703791, compound

HRID 1849913Notes

Reaction equation

HRID 1849913 reaction equation
[Cl:1][C:2]1[C:3]([O:16][CH2:17][CH:18]2[CH2:23][CH2:22][CH2:21][C:20]([F:25])([F:24])[CH2:19]2)=[CH:4][C:5]([F:15])=[C:6]([CH:14]=1)[C:7]([O:9]C(C)(C)C)=[O:8]>ClCCl.FC(F)(F)C(O)=O>[Cl:1][C:2]1[C:3]([O:16][CH2:17][CH:18]2[CH2:23][CH2:22][CH2:21][C:20]([F:24])([F:25])[CH2:19]2)=[CH:4][C:5]([F:15])=[C:6]([CH:14]=1)[C:7]([OH:9])=[O:8]

Participants

4

Reactant 1

HCID 86703792HCID 86703792, compound

Product 1

HCID 86703791HCID 86703791, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of tert-butyl 5-chloro-4-((3,3-difluorocyclohexyl)methoxy)-2- fluorobenzoate (64.4 mg) in dichloromethane (0.34 mL) and trifluoroacetic acid (0.17 mL) was stirred at 0° C. for 10 min then at rt for 2 h. The contents were concentrated. The residue was re-dissolved with dichloromethane and concentrated. The crude was dried under vacuum and used directly.

Workup

  1. concentrationThe contents were concentrated
  2. dissolutionThe residue was re-dissolved with dichloromethane
  3. concentrationconcentrated
  4. customThe crude was dried under vacuum

Sources & evidence

ORD record
ord-c1f84c02fd7e4cc4924c2c1418cade19
Source dataset
uspto-grants-2015_02
Patent number
US08952169B2

Reaction notes

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