反应详情

温度

80 °C

Under a nitrogen atmosphere, a mixed solution of 1500 g of 1-naphthol, 1032 g of 2-methoxyethyl chloride, 460 g of sodium hydroxide, 78 g of sodium iodide, and 3000 g of ethanol was stirred for 37 hours with heating at 80° C. After cooling, 3000 g of water and 5000 g of toluene were added to the mixed solution, and then the organic layer was separated and washed by 1800 g of an aqueous sodium hydroxide (concentration of 5% by mass) for five times. Then, after washed by 1800 g of water for four times, the organic layer was concentrated to obtain 1835 g of an oily substance. This was distilled under reduced pressure (at 110° C. and 13 Pa) to obtain 1637 g of the intended product (Yield 77%).

1. temperatureAfter cooling
2. customthe organic layer was separated
3. washwashed by 1800 g of an aqueous sodium hydroxide (concentration of 5% by mass) for five times
4. washThen, after washed by 1800 g of water for four times
5. concentrationthe organic layer was concentrated
6. customto obtain 1835 g of an oily substance
7. distillationThis was distilled under reduced pressure (at 110° C. and 13 Pa)