Methanol → HCID 178513316, compound

HRID 1849996Notes

Reaction equation

HRID 1849996 reaction equation
[C:1](#[N:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[NH2:10][OH:11].[CH3:12][OH:13]>>[OH:11][NH:10][C:1](=[NH:8])[C:2]1[CH:7]=[CH:6][C:5]([CH2:12][OH:13])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 7505BenzonitrileHCID 443297Hydroxyamine hydrochloride

Product 1

HCID 178513316HCID 178513316, compound

Conditions

Temperature
50 °C

Procedure

To a solution of the benzonitrile intermediate in methanol was added hydroxylamine hydrochloride. After heating to 50° C. with stirring for 16 h, the reaction mixture was cooled to RT and concentrated to afford the corresponding N-hydroxy-4-(hydroxymethyl)benz-imidamide derivative.

Workup

  1. temperaturethe reaction mixture was cooled to RT
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-8ff974435db34826b6ee389080fb1a2c
Source dataset
uspto-grants-2015_02
Patent number
US08957051B2

Reaction notes

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