Hydrochloric Acid → HCID 67997439, compound

HRID 1850252Notes

Reaction equation

HRID 1850252 reaction equation
[ClH:1].C(OC([N:9]1[CH2:12][CH:11]([C:13]2[C:18]([C:19]3[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=3)=[N:17][CH:16]=[CH:15][N:14]=2)[CH2:10]1)=O)(C)(C)C>CO>[ClH:1].[NH:9]1[CH2:12][CH:11]([C:13]2[C:18]([C:19]3[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=3)=[N:17][CH:16]=[CH:15][N:14]=2)[CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58547404HCID 58547404, compound

Product 1

HCID 67997439HCID 67997439, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 4 N HCl in MeOH (10 mL) was added (21) (120 mg, 0.35 mmol) at 0° C. and the resulting mixture was stirred at RT for 1 h. The mixture was concentrated under reduced pressure to give 2-azetidin-3-yl-3-(4-methoxy-phenyl)-pyrazine (22) (95 mg, yield 100%) which was used for the next step without further purification. ESI-MS (M+1): 242 calc. for C14H15N3O 241.

Workup

  1. concentrationThe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-08c9999a439a4900be8f78762c3337a2
Source dataset
uspto-grants-2015_02
Patent number
US08957073B2

Reaction notes

Loading…