Sodium Methoxide → HCID 58483120, compound

HRID 1850804Notes

Reaction equation

HRID 1850804 reaction equation
Cl[C:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([N:18]([CH3:20])[CH3:19])=[C:14]([CH3:21])[CH:13]=2)[CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2.[CH3:22][O-:23].[Na+]>CC(N(C)C)=O>[CH3:22][O:23][C:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([N:18]([CH3:20])[CH3:19])=[C:14]([CH3:21])[CH:13]=2)[CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 446328825-Chloro-7-(4-dimethylamino-3-methylphenyl)-[1,6]naphthyridine

Product 1

HCID 58483120HCID 58483120, compound

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Conditions

Temperature
50 °C

Procedure

100 mg (0.31 mmol) of 6.1 was placed in 0.5 ml dimethylacetamide and then 60 mg (1.1 mmol) sodium methoxide were added. The reaction mixture was stirred for 1 h at 50° C. The mixture was purified by chromatography (RP-HPLC-MS), the corresponding fractions were freeze-dried.

Workup

  1. customThe mixture was purified by chromatography (RP-HPLC-MS)
  2. customthe corresponding fractions were freeze-dried

Sources & evidence

ORD record
ord-9fd2f608e47c4136bef18f3794eba00f
Source dataset
uspto-grants-2015_02
Patent number
US08957088B2

Reaction notes

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