反应详情

To a solution of 5 g 5-Chloro-pyridin-2-ylamine and 1.5 mL pyridine in 30 mL toluene, 8 g bromo-acetyl bromide dissolved in 10 mL toluene were added dropwise under ice cooling. After 2 h the precipitate was isolated by filtration and recrystallized from toluene to yield a white solid.

1. additionwere added dropwise under ice cooling
2. customAfter 2 h the precipitate was isolated by filtration
3. customrecrystallized from toluene
4. customto yield a white solid