Pyridine-2-carbonitrile → Picolinimidohydrazide

HRID 1851239Notes

Reaction equation

HRID 1851239 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]#[N:8].O.[NH2:10][NH2:11]>C(O)C.O>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7](=[N:10][NH2:11])[NH2:8]

Participants

5

Reactant 2

HCID 7522Pyridine-2-carbonitrileHCID 24654Hydrazine hydrate (1:1)

Product 1

HCID 70493Picolinimidohydrazide

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A solution of pyridine-2-carbonitrile 20 g (192 mmol) and hydrazine hydrate (3 Eq.) in ethanol (50 mL) was stirred at room temperature for 18 hrs. The reaction mass was then diluted with water, extracted with ethyl acetate, and the organic portion dried (Na2SO4) and concentrated in vacuo to yield the desired compound.

Workup

  1. extractionextracted with ethyl acetate
  2. dry with materialthe organic portion dried (Na2SO4)
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-f33b059b20a64d91877dedd375fc6cef
Source dataset
uspto-grants-2015_02
Patent number
US08957064B2

Reaction notes

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