Diisopropyl Ether → HCID 178496780, compound

HRID 1851361Notes

Reaction equation

HRID 1851361 reaction equation
[CH3:1][O:2][CH2:3][N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[N:13]([CH2:22][O:23][CH3:24])[S:14]([C:17]2[S:18][CH:19]=[CH:20][CH:21]=2)(=[O:16])=[O:15])[CH:6]=[C:5]1[C:25]([NH2:27])=[O:26].C(OC(C)C)(C)C>COC(OC)N(C)C>[CH3:3][N:4](/[CH:12]=[N:27]/[C:25]([C:5]1[N:4]([CH2:3][O:2][CH3:1])[C:12]2[C:7]([CH:6]=1)=[CH:8][CH:9]=[CH:10][C:11]=2[N:13]([CH2:22][O:23][CH3:24])[S:14]([C:17]1[S:18][CH:19]=[CH:20][CH:21]=1)(=[O:16])=[O:15])=[O:26])[CH3:5]

Participants

4

Reactant 2

HCID 7914Diisopropyl EtherHCID 57901741HCID 57901741, compound

Product 1

HCID 178496780HCID 178496780, compoundYield 186.9%

Reagents, catalysts & solvents 1

HCID 78373Dimethylformamide dimethyl acetalSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of 1-(methoxymethyl)-7-[(methoxymethyl)(2-thienylsulfonyl)amino]-1H-indole-2-carboxamide (1.00 g) and N,N-dimethylformamide dimethyl acetal (10 mL) was stirred at 50° C. overnight. To the reaction mixture was added diisopropyl ether, and the resulting crystals were filtrated and dried to give the title compound (1.06 g, yield 93%) as colorless crystals. melting point 146-147° C.

Workup

  1. filtrationthe resulting crystals were filtrated
  2. customdried

Sources & evidence

ORD record
ord-c10154ba043c4eac8c9c693d2e7c2c91
Source dataset
uspto-grants-2015_02
Patent number
US08957070B2

Reaction notes

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