Hydrochloric Acid → HCID 136060828, compound

HRID 1851508Notes

Reaction equation

HRID 1851508 reaction equation
COC[N:4]([C:13]1[CH:14]=[CH:15][CH:16]=[C:17]2[C:21]=1[N:20](COC)[C:19]([C:25]1[N:29]=[CH:28][N:27]([CH3:30])[N:26]=1)=[CH:18]2)[S:5]([C:8]1[S:9][CH:10]=[CH:11][CH:12]=1)(=[O:7])=[O:6].Cl.C(=O)(O)[O-].[Na+]>CO>[CH3:30][N:27]1[CH:28]=[N:29][C:25]([C:19]2[NH:20][C:21]3[C:17]([CH:18]=2)=[CH:16][CH:15]=[CH:14][C:13]=3[NH:4][S:5]([C:8]2[S:9][CH:10]=[CH:11][CH:12]=2)(=[O:6])=[O:7])=[N:26]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 57901863HCID 57901863, compound

Product 1

HCID 136060828HCID 136060828, compoundYield 20.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

N-(Methoxymethyl)-N-[1-(methoxymethyl)-2-(1-methyl-1H-1,2,4-triazol-3-yl)-1H-indol-7-yl]thiophene-2-sulfonamide (0.42 g), concentrated hydrochloric acid (1 mL) and methanol (6 mL) were heated under reflux for 6 hr. The reaction mixture was neutralized with aqueous sodium bicarbonate, and the resulting crystals were filtrated, washed with water, and dried to give the title compound (0.07 g, yield 20%) as colorless crystals. The crystals were recrystallized from ethyl acetate. melting point>161° C. (decomposition).

Workup

  1. temperatureunder reflux for 6 hr
  2. filtrationthe resulting crystals were filtrated
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-f69c3fe1e9b9412db4faeab505bdb23d
Source dataset
uspto-grants-2015_02
Patent number
US08957070B2

Reaction notes

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