Ammonia → 2-phenyl-4H,5H,6H,7H-(1,3)thiazolo(5,4-c)pyridine

HRID 1851668Notes

Reaction equation

HRID 1851668 reaction equation
[C:1]([NH2:9])(=[S:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH3:10]>CN(C=O)C>[C:2]1([C:1]2[S:8][C:3]3[CH2:4][NH:10][CH2:6][CH2:7][C:2]=3[N:9]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 683563Thiobenzamide

Product 1

HCID 223374872-phenyl-4H,5H,6H,7H-(1,3)thiazolo(5,4-c)pyridine

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

4.5 g of the product of step a) are charged to a round-bottomed flask with 34 ml of DMF and 2.6 g of thiobenzamide. Heating is carried out at a temperature of 60° C. for 6 hours. An aqueous ammonia solution is added until a basic pH is obtained and evaporation is carried out under vacuum.

Workup

  1. temperatureHeating
  2. customis obtained
  3. customevaporation

Sources & evidence

ORD record
ord-567c8c68018b474d891e6d3a1ec1bf39
Source dataset
uspto-grants-2015_02
Patent number
US08957211B2

Reaction notes

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