反应详情

温度

180 °C

4-(allyloxy)-1-chloroisoquinoline (1.0 g, 4.55 mmol) was dissolved in diglyme (5 mL) and heated to 180° C. for 1 h. The reaction was cooled down to rt before adding EtOAc and water. Washed EtOAc layer with water then brine solution. The organic layer was then dried and concentrated. The residue was purified by flash chromatography with 20% of EtOAc/hexane to afford 3-allyl-1-chloroisoquinolin-4-ol (670 mg, 67%) as product. MS: MS m/z 220.1 (M++1).

1. temperatureThe reaction was cooled down to rt
2. customThe organic layer was then dried
3. concentrationconcentrated
4. customThe residue was purified by flash chromatography with 20% of EtOAc/hexane