Hydrochloric Acid → HCID 56960272, compound

HRID 1852414Notes

Reaction equation

HRID 1852414 reaction equation
[OH-].[Na+].C([N:6]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:7]([C:9]1[C:10](=[O:24])[N:11]([CH3:23])[C:12]2[C:17]([C:18]=1[O:19][C:20](=[O:22])[CH3:21])=[CH:16][CH:15]=[CH:14][CH:13]=2)=[O:8])(=O)C.Cl>CO.C1COCC1.O>[C:25]1([NH:6][C:7]([C:9]2[C:10](=[O:24])[N:11]([CH3:23])[C:12]3[C:17]([C:18]=2[O:19][C:20](=[O:22])[CH3:21])=[CH:16][CH:15]=[CH:14][CH:13]=3)=[O:8])[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

7

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 56960271HCID 56960271, compound

Product 1

HCID 56960272HCID 56960272, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolvent2×HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of NaOH in MeOH (0.50 mL, 0.20 M, 0.10 mmol) was added to a solution of N-acetyl-N-phenyl-4-acetoxy-1,2-dihydro-1-methyl-2-oxo-quinoline-3-carboxamide (38 mg, 0.10 mmol) in MeOH (1.0 mL) and THF (0.5 mL). After stirring for 3 min, the solution was neutralized with aq. HCl (0.2 mL, 0.5 M) and further diluted with water (ca 10 mL). The precipitated product (29 mg, 86%) was collected by filtration and washed with water.

Workup

  1. filtrationThe precipitated product (29 mg, 86%) was collected by filtration
  2. washwashed with water

Sources & evidence

ORD record
ord-cf5cc62466b244f3899f1aff06aa61d7
Source dataset
uspto-grants-2015_02
Patent number
US08962598B2

Reaction notes

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