2,2,2-Trifluoroethanol → HCID 86729358, compound

2,2,2-Trifluoroethanol (1.6 mL, 22 mmol) and TEA (6.2 mL, 45 mmol) were dissolved in MeCN (200 mL). N,N-disuccinimidyl carbonate (8.6 g, 34 mmol) was added and the resulting mixture was stirred at ambient temperature for 90 minutes. 4-(cyanomethylidene)piperidinium trifluoroacetate (5.3 g, 23 mmol) in DMSO (10 mL) was then added, followed by TEA (6.2 mL, 45 mmol). The resulting mixture was stirred at 50° C. for 16 hours. The reaction mixture was cooled to ambient temperature, diluted with EtOAc and washed sequentially with saturated aqueous NaHCO3 and water. The organic layer was dried over anhydrous MgSO4, filtered, and concentrated in vacuo. The residue was purified by MPLC on silica gel (using a gradient elution of 0-5% MeOH/DCM) to afford the title compound. LRMS (ESI) calc'd for C10H11F3N2O2 [M+H]+: 249. Found: 249.

1. stirringThe resulting mixture was stirred at 50° C. for 16 hours
2. temperatureThe reaction mixture was cooled to ambient temperature
3. washwashed sequentially with saturated aqueous NaHCO3 and water
4. dry with materialThe organic layer was dried over anhydrous MgSO4
5. filtrationfiltered
6. concentrationconcentrated in vacuo
7. customThe residue was purified by MPLC on silica gel (
8. washa gradient elution of 0-5% MeOH/DCM)

ORD record

ord-0d1e8bae207d486c8f9eec32b23ef780

Source dataset

uspto-grants-2015_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08962608B2