Hydrochloric Acid → HCID 67459438, compound

HRID 1853070Notes

Reaction equation

HRID 1853070 reaction equation
[C:1]([CH2:3][C:4]1([N:15]2[CH:19]=[C:18]([C:20]3[N:25]4[CH:26]=[CH:27][N:28]=[C:24]4[CH:23]=[C:22]([CH:29]4[CH2:31][CH2:30]4)[N:21]=3)[CH:17]=[N:16]2)[CH2:7][N:6](C(OC(C)(C)C)=O)[CH2:5]1)#[N:2].[ClH:32]>O1CCOCC1>[ClH:32].[ClH:32].[ClH:32].[CH:29]1([C:22]2[N:21]=[C:20]([C:18]3[CH:17]=[N:16][N:15]([C:4]4([CH2:3][C:1]#[N:2])[CH2:7][NH:6][CH2:5]4)[CH:19]=3)[N:25]3[CH:26]=[CH:27][N:28]=[C:24]3[CH:23]=2)[CH2:31][CH2:30]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67457983HCID 67457983, compound

Product 1

HCID 67459438HCID 67459438, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of tert-butyl 3-(cyanomethyl)-3-(4-(7-cyclopropylimidazo[1,2-c]pyrimidin-5-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate (100 mg; 0.238 mmol) in 1,4-dioxane (1 mL) was added hydrogen chloride in 1,4-dioxane (2.4 mL; 4M solution). The mixture was stirred in a sealed vial for 3 hours. The solvent was removed under reduced pressure to give the product (100 mg) as an off white solid. MS (apci) m/z=320.1 (M+H).

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-471f719699fc49149bc96f2e0a469bc7
Source dataset
uspto-grants-2015_02
Patent number
US08962596B2

Reaction notes

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