反应详情

A solution of 769 mg 2-Trichloromethyl-1H-benzoimidazole in 10 mL THF were slowly added to a mixture containing 304 mg 1-(4-Amino-phenyl)-1H-pyridin-4-one, 1.3 g NaHCO3, 40 mL THF and 15 mL H2O. The mixture was stirred vigorously for 3 h at room temperature, diluted with 200 mL CH2Cl2 and washed with 40 mL of a saturated NaHCO3-solution. The aqueous solution was extracted with CH2Cl2 (3×200 ml) and the combined organic layers were dried over MgSO4 and concentrated under reduced pressure to give a brown solid, which was pure enough for the following reactions.

1. washwashed with 40 mL of a saturated NaHCO3-solution
2. extractionThe aqueous solution was extracted with CH2Cl2 (3×200 ml)
3. dry with materialthe combined organic layers were dried over MgSO4
4. concentrationconcentrated under reduced pressure
5. customto give a brown solid, which