HRID1853303

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID94308

Dimethylaminopropyl chloride hydrochloride

C5H13Cl2N

结构：CC(C)(C)ON=c1cc(-c2cc3cccn3cn2)oc2ccc(O)cc12

HCID86673073

未命名化合物

PRODUCTS

生成物

结构：CN(C)CCCOc1ccc2oc(-c3cc4cccn4cn3)cc(=NO)c2c1

HCID75964528

未命名化合物

结构：CN(C)CCCOc1ccc2oc(-c3cc4cccn4cn3)cc(=NO)c2c1.Cl

HCID86673072

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

6-(3-Dimethylamino-propoxy)-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one oxime was prepared in 22% overall yield using the procedure described in example 42A, starting from 6-hydroxy-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one O-tert-butyl oxime (example 81A) and (3-Chloro-propyl)-dimethyl-amine hydrochloride. The compound was treated with a 1.25 N solution of hydrogen chloride in isopropanol to yield 6-(3-Dimethylamino-propoxy)-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one oxime hydrochloride as an orange solid.

WORKUP

后处理

customoverall yield

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b4e2cc76e9e143e499b4714d4c2b00c9
来源数据集: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08962627B2
来源说明: uspto-grants-2015_02

反应 SMILES

C([O:5][N:6]=[C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([OH:17])[CH:15]=2)[O:10][C:9]([C:18]2[N:23]=[CH:22][N:21]3[CH:24]=[CH:25][CH:26]=[C:20]3[CH:19]=2)=[CH:8]1)(C)(C)C.Cl.[Cl:28][CH2:29][CH2:30][CH2:31][N:32]([CH3:34])[CH3:33].Cl>C(O)(C)C>[CH3:33][N:32]([CH3:34])[CH2:31][CH2:30][CH2:29][O:17][C:14]1[CH:15]=[C:16]2[C:11](=[CH:12][CH:13]=1)[O:10][C:9]([C:18]1[N:23]=[CH:22][N:21]3[CH:24]=[CH:25][CH:26]=[C:20]3[CH:19]=1)=[CH:8][C:7]2=[N:6][OH:5].[ClH:28].[CH3:33][N:32]([CH3:34])[CH2:31][CH2:30][CH2:29][O:17][C:14]1[CH:15]=[C:16]2[C:11](=[CH:12][CH:13]=1)[O:10][C:9]([C:18]1[N:23]=[CH:22][N:21]3[CH:24]=[CH:25][CH:26]=[C:20]3[CH:19]=1)=[CH:8][C:7]2=[N:6][OH:5]