Dimethylformamide → HCID 86673114, compound

HRID 1853354Notes

Reaction equation

[C:1]([O:5][N:6]=[C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[O:10][C:9]([C:17]2[N:22]=[CH:21][N:20]3[C:23](O)=[CH:24][CH:25]=[C:19]3[CH:18]=2)=[CH:8]1)([CH3:4])([CH3:3])[CH3:2].Br[CH2:28][CH2:29][CH2:30][Cl:31].CN(C)C=[O:35]>>[C:1]([O:5][N:6]=[C:7]1[C:16]2[C:11](=[CH:12][C:13]([O:35][CH2:28][CH2:29][CH2:30][Cl:31])=[CH:14][CH:15]=2)[O:10][C:9]([C:17]2[N:22]=[CH:21][N:20]3[CH:23]=[CH:24][CH:25]=[C:19]3[CH:18]=2)=[CH:8]1)([CH3:2])([CH3:3])[CH3:4]

Participants

Reactant 3

HCID 6228Dimethylformamide

HCID 80061-Bromo-3-chloropropane

HCID 136352241HCID 136352241, compound

Product 1

HCID 86673114HCID 86673114, compoundYield 100%

Procedure

7-(3-Chloro-propoxy)-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one O-tert-butyl-oxime was prepared in 100% yield using the method described in example 85A, starting from 7-Hydroxy-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one O-tert-butyl-oxime (example 142B) and 1-bromo-3-chloropropane in dimethylformamide. The title compound was isolated as a brown solid.

Sources & evidence

ORD record: ord-51d5f5f7d2fd4381b6918ea09e7e680b
Source dataset: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08962627B2

Reaction notes

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