6-Hydroxy-2-thieno[3,2-c]pyridin-6-yl-chromen-4-one O-tert-butyl-oxime → 6-(1-Pyrimidin-2-yl-piperidin-4-yloxy)-2-thieno[3,2-c]pyridin-6-yl-chromen-4-one O-tert-butyl-oxime

HRID 1853371Notes

Reaction equation

HRID 1853371 reaction equation
[C:1]([O:5][N:6]=[C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([OH:17])[CH:15]=2)[O:10][C:9]([C:18]2[N:23]=[CH:22][C:21]3[CH:24]=[CH:25][S:26][C:20]=3[CH:19]=2)=[CH:8]1)([CH3:4])([CH3:3])[CH3:2].[N:27]1[CH:32]=[CH:31][CH:30]=[N:29][C:28]=1[N:33]1[CH2:38][CH2:37][CH:36](OS(C)(=O)=O)[CH2:35][CH2:34]1>CN(C)C=O>[C:1]([O:5][N:6]=[C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:17][CH:36]3[CH2:37][CH2:38][N:33]([C:28]4[N:27]=[CH:32][CH:31]=[CH:30][N:29]=4)[CH2:34][CH2:35]3)[CH:15]=2)[O:10][C:9]([C:18]2[N:23]=[CH:22][C:21]3[CH:24]=[CH:25][S:26][C:20]=3[CH:19]=2)=[CH:8]1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 866731016-Hydroxy-2-thieno[3,2-c]pyridin-6-yl-chromen-4-one O-tert-butyl-oximeHCID 86673125Methanesulfonic acid 1-pyrimidin-2-yl-piperidin-4-yl ester

Product 1

HCID 866731246-(1-Pyrimidin-2-yl-piperidin-4-yloxy)-2-thieno[3,2-c]pyridin-6-yl-chromen-4-one O-tert-butyl-oxime

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

6-(1-Pyrimidin-2-yl-piperidin-4-yloxy)-2-thieno[3,2-c]pyridin-6-yl-chromen-4-one O-tert-butyl-oxime was prepared using the procedure described in example 85A, starting from 6-Hydroxy-2-thieno[3,2-c]pyridin-6-yl-chromen-4-one O-tert-butyl-oxime (example 127B) and methanesulfonic acid 1-pyrimidin-2-yl-piperidin-4-yl ester (example 169B) in dimethylformamide.

Sources & evidence

ORD record
ord-b10a5b5de8a049dab3110bea34256923
Source dataset
uspto-grants-2015_02
Patent number
US08962627B2

Reaction notes

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