Hydrochloric Acid → HCID 86689471, compound

HRID 1853708Notes

Reaction equation

HRID 1853708 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]([CH3:13])[C:10]2[NH:9][C:8](=[O:14])[C:7]3[S:15][CH:16]=[CH:17][C:6]=3[C:5]=2[C:4]=1[C:18]1[CH:23]=[CH:22][C:21]([CH:24]2[CH2:29][CH2:28][CH2:27][N:26](C(OC(C)(C)C)=O)[CH2:25]2)=[CH:20][CH:19]=1.[ClH:37]>CCOCC>[ClH:37].[CH3:1][O:2][C:3]1[CH:12]=[C:11]([CH3:13])[C:10]2[NH:9][C:8](=[O:14])[C:7]3[S:15][CH:16]=[CH:17][C:6]=3[C:5]=2[C:4]=1[C:18]1[CH:19]=[CH:20][C:21]([CH:24]2[CH2:29][CH2:28][CH2:27][NH:26][CH2:25]2)=[CH:22][CH:23]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67450616HCID 67450616, compound

Product 1

HCID 86689471HCID 86689471, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Following General Procedure D1, tert-butyl 3-(4-(8-methoxy-6-methyl-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9-yl)phenyl)piperidine-1-carboxylate (50 mg, 0.10 mmol) was reacted with HCl in ether (2.5 mL) to afford the desired product (31 mg, 77%) as an off-white solid: ESI MS m/z 405 [C24H24N2O2S+H]+

Sources & evidence

ORD record
ord-1135af703c2e41258a318a77aed4df5c
Source dataset
uspto-grants-2015_02
Patent number
US08962648B2

Reaction notes

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