反应详情

温度

90 °C

To a solution of hex-3-yn-2-one (1.5 g, 15.6 mmol) in 90% ethanol (30 mL), cyanoacetamide (1.58 g, 18.72 mmol) and piperidine acetate {prepared by the addition of piperidine to a solution of acetic acid (0.258 mL) in water (0.65 mL) till pH 8} were added and reaction heated at 90° C. for 12 h. On completion, ethanol was evaporated and water was added to residue. Solid obtained was filtered and washed with water. Then this solid was stirred with acetonitrile for 10 min and filtered again to obtain the desired intermediate (1.5 g, 60%).

1. additionwere added
2. customreaction
3. customOn completion, ethanol was evaporated
4. additionwater was added to residue
5. customSolid obtained
6. filtrationwas filtered
7. washwashed with water
8. filtrationfiltered again