Ethylmorpholine → HCID 70664958, compound

HRID 1854533Notes

Reaction equation

HRID 1854533 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:10]=[C:9]([NH2:11])[N:8]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:7]=1)=[O:5])[CH3:2].C(N1CCOCC1)C.[CH3:26][C:27]([CH3:32])([CH3:31])[C:28](Cl)=[O:29]>C1COCC1>[CH2:1]([O:3][C:4]([C:6]1[CH:10]=[C:9]([NH:11][C:28](=[O:29])[C:27]([CH3:32])([CH3:31])[CH3:26])[N:8]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:7]=1)=[O:5])[CH3:2]

Participants

5

Reactant 3

HCID 7525EthylmorpholineHCID 62493Pivaloyl chlorideHCID 23630921Ethyl 5-amino-1-phenyl-1H-pyrazole-3-carboxylate

Product 1

HCID 70664958HCID 70664958, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3 g (12.97 mmol) of 5-Amino-1-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester are dissolved in 100 ml of THF, 1.6 ml (1.49 g, 12.97 mmol, 1 eq) of N-ethylmorpholine and 1.56 f (12.97 mmol, 1 eq) of trimethylacetylchloride are added and the resulting mixture is stirred overnight at RT. The solvent is removed in vacuo and the crude material obtained (3.8 g, Yield: 93%) is used in the following steps without further purification.

Workup

  1. customThe solvent is removed in vacuo

Sources & evidence

ORD record
ord-03bfbcdd0c4c40c095ca5de4f4cd00e9
Source dataset
uspto-grants-2015_02
Patent number
US08962671B2

Reaction notes

Loading…