Phenol, 2-chloro-5-(trifluoromethyl)- → HCID 53494183, compound

HRID 1854817Notes

Reaction equation

HRID 1854817 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[OH:12].[N:13]1[CH:18]=[CH:17][N:16]=[C:15]([N:19]2[CH2:23][CH2:22][CH:21](O)[CH2:20]2)[N:14]=1.CC(OC(/N=N/C(OC(C)C)=O)=O)C>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:10])([F:11])[F:9])=[CH:4][C:3]=1[O:12][CH:21]1[CH2:22][CH2:23][N:19]([C:15]2[N:14]=[N:13][CH:18]=[CH:17][N:16]=2)[CH2:20]1

Participants

5

Reactant 3

HCID 123498Phenol, 2-chloro-5-(trifluoromethyl)-HCID 5363146Diisopropyl azodicarboxylateHCID 86676671HCID 86676671, compound

Product 1

HCID 53494183HCID 53494183, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Compound 42 is prepared from 2-chloro-5-trifluoromethylphenol and intermediate 5d according to synthesis method 3 in toluene in the presence of DIAD, under the operating conditions described for example 8 (86% yield).

Sources & evidence

ORD record
ord-6e5eeab055cd47dd9bbe89efe1644e4f
Source dataset
uspto-grants-2015_02
Patent number
US08962837B2

Reaction notes

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