Triethylamine → [3-Methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-[5-methyl-4-(1-phenyl-ethyl)-pyrimidin-2-yl]-amine

HRID 1855332Notes

Reaction equation

HRID 1855332 reaction equation
[N+]([O-])(O)=O.[N+]([O-])(O)=O.[CH3:9][O:10][C:11]1[CH:12]=[C:13]([NH:23][C:24]([NH2:26])=[NH:25])[CH:14]=[CH:15][C:16]=1[N:17]1[CH:21]=[C:20]([CH3:22])[N:19]=[CH:18]1.CN(C)[CH:29]=[C:30]([CH3:41])[C:31](=O)[CH:32]([C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)[CH3:33].C(N(CC)CC)C>CN1CCCC1=O>[CH3:9][O:10][C:11]1[CH:12]=[C:13]([NH:23][C:24]2[N:26]=[C:31]([CH:32]([C:34]3[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=3)[CH3:33])[C:30]([CH3:41])=[CH:29][N:25]=2)[CH:14]=[CH:15][C:16]=1[N:17]1[CH:21]=[C:20]([CH3:22])[N:19]=[CH:18]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 686313161-Dimethylamino-2-methyl-4-phenyl-pent-1-en-3-oneHCID 178493228HCID 178493228, compound

Product 1

HCID 44192596[3-Methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-[5-methyl-4-(1-phenyl-ethyl)-pyrimidin-2-yl]-amine

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

The title compound was prepared in analogous manner described in example 4c) from N-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-guanidine dinitrate, 1-dimethylamino-2-methyl-4-phenyl-pent-1-en-3-one and triethylamine using 1-methyl-2-pyrrolidinone as the solvent. The reaction was performed in a microwave at 200° C. for 30 min. The title compound was isolated as a pale-yellow solid in 39% yield.

Workup

  1. customThe title compound was prepared in analogous manner

Sources & evidence

ORD record
ord-3ca6af2389534bc8ab6fa72dac301390
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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