2-Amino-2-methyl-1-propanol → HCID 62342457, compound

HRID 1855450Notes

Reaction equation

HRID 1855450 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[NH2:9][C:10]([CH3:14])([CH3:13])[CH2:11][OH:12]>>[Cl:1][C:2]1[N:7]=[C:6]([NH:9][C:10]([CH3:14])([CH3:13])[CH2:11][OH:12])[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 118072-Amino-2-methyl-1-propanolHCID 775312,4-Dichloropyrimidine

Product 1

HCID 62342457HCID 62342457, compoundYield 19%

Procedure

Prepared in analogy to example 98a), using 2,4-dichloro-pyrimidine and 2-amino-2-methylpropan-1-ol. The title compound was isolated as a yellowish solid in a yield of 19%. MS ISP (m/e): 200.3 (100) [(M+H)+]. 1H NMR (DMSO-D6, 300 MHz): δ (ppm)=7.84 (d, 1H), 7.49 (s, 1H), 6.50 (d, 1H), 4.85 (s, 1H), 3.53 (d, 2H), 1.29 (s, 6H).

Workup

  1. customPrepared in analogy to example 98a),

Sources & evidence

ORD record
ord-7f04572b2ae94744a1724b71e10e249e
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

Loading…