反应详情

温度

100 °C

To 500 mg (1.44 mmol) of methyl (S)-2-{3-[2-(1H-imidazol-4-yl)ethyl]ureido}-3-(4-methoxyphenyl)propanoate are added 500 mg of lithium hydroxide, 7 ml of tetrahydrofuran and 2 ml of water. The reaction medium is placed in a microwave reactor with stirring, at 100° C. for 10 minutes. Seven other identical tests are performed. The various tests are combined and concentrated to dryness. The crude product obtained is purified by filtration on a pad of silica (eluent: 1/1 dichloromethane/methanol). 2.73 g of 2-{3-[2-(1H-imidazol-4-yl)ethyl]ureido}-3-(4-methoxyphenyl)propanoic acid in the form of a pale yellow powder are obtained in a yield of 70%.

1. customThe reaction medium is placed in a microwave reactor
2. concentrationconcentrated to dryness
3. customThe crude product obtained
4. filtrationis purified by filtration on a pad of silica (eluent: 1/1 dichloromethane/methanol)