Chlorine → 2-Chloro-4-(trifluoromethyl)phenol

HRID 1855686Notes

Reaction equation

HRID 1855686 reaction equation
[Cl:1]Cl.[F:3][C:4]([F:13])([F:12])[C:5]1[CH:6]=[CH:7][C:8]([OH:11])=[CH:9][CH:10]=1>C(Cl)CCl>[Cl:1][C:9]1[C:8]([OH:11])=[CH:7][CH:6]=[C:5]([C:4]([F:12])([F:13])[F:3])[CH:10]=1

Participants

4

Reactant 2

HCID 24526ChlorineHCID 678744-(Trifluoromethyl)phenol

Product 1

HCID 27366032-Chloro-4-(trifluoromethyl)phenolYield 71%

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

Chlorine gas is passed through a flow meter into a solution of α,α,α-trifluoro-p-cresol (4.05 g. 0.025 mole) in ethylene dichloride (200 ml.) at 0° C. until the theoretical volume has been absorbed. The solvent is stripped off and the residue distilled to give 2-chloro-α,α,α-trifluoro-p-cresol (3.5 g. 71%) b.p. 80°-82° C. at 33 mm.

Workup

  1. customhas been absorbed
  2. distillationthe residue distilled

Sources & evidence

ORD record
ord-33acdb3cf3ce424da9cda8126d67f415
Source dataset
uspto-grants-1980_08
Patent number
USRE030361

Reaction notes

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