Hydrochloric Acid → HCID 23348503, compound

HRID 1855747Notes

Reaction equation

HRID 1855747 reaction equation
C([O:3][C:4](=[O:26])[CH2:5][CH2:6][NH:7][C:8]([NH:10][CH2:11][CH2:12][CH2:13][N:14]1[CH2:19][CH2:18][N:17]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:16][CH2:15]1)=[O:9])C.[OH-].[Na+].Cl>CC(C)=O>[C:20]1([N:17]2[CH2:18][CH2:19][N:14]([CH2:13][CH2:12][CH2:11][NH:10][C:8](=[O:9])[NH:7][CH2:6][CH2:5][C:4]([OH:26])=[O:3])[CH2:15][CH2:16]2)[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 54209415HCID 54209415, compound

Product 1

HCID 23348503HCID 23348503, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

19.0 g (0.0524 mol) of this ester are dissolved in 250 ml of acetone and mixed with 52.4 ml of N sodium hydroxide solution. The mixture is stirred at room temperature for 18 hours, 52.4 ml of N hydrochloric acid are added, the mixture is evaporated and the residue is re-crystallised from methanol, to yield 3-{3-[3-(4-phenyl-1-piperazinyl)-propyl]-ureido}propionic acid. Yield: 15.9 g (90% of theory). Melting range: 169°-171° C. ##STR27##

Workup

  1. customthe mixture is evaporated
  2. customthe residue is re-crystallised from methanol

Sources & evidence

ORD record
ord-293636db59a84a3bbe9620887173de2f
Source dataset
uspto-grants-1980_08
Patent number
US04216216

Reaction notes

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