Methyl iodide → HCID 136045968, compound

HRID 1855866Notes

Reaction equation

HRID 1855866 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:8]2[C:9](=[O:16])[NH:10][C:11](=[S:15])[NH:12][C:13]=2[CH3:14])[CH:2]=1.CI.[O-][CH2:20]C.[Na+]>C(O)C>[CH3:20][S:15][C:11]1[NH:10][C:9](=[O:16])[C:8]([CH2:7][C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)=[C:13]([CH3:14])[N:12]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 2723922Sodium ethoxideHCID 23349180HCID 23349180, compound

Product 1

HCID 136045968HCID 136045968, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Treatment of 5-(3-pyridylmethyl)-6-methyl-2-thiouracil with methyl iodide and sodium ethoxide in ethanol at 0° followed by acidification gave 2-methylthio-5-(3-pyridylmethyl)-6-methyl-4-pyrimidone m.p. 208°-211°.

Workup

  1. customat 0°

Sources & evidence

ORD record
ord-76972377ce3645a6b157e5bb8f1f61a2
Source dataset
uspto-grants-1980_08
Patent number
US04216318

Reaction notes

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