Potassium Carbonate → HCID 12805107, compound

HRID 1855888Notes

Reaction equation

HRID 1855888 reaction equation
C1(C)C=CC(S(O[CH2:11][CH:12]([C:14]2[CH:19]=[CH:18][C:17]([C:20](=[O:27])[C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[CH:16][CH:15]=2)[CH3:13])(=O)=O)=CC=1.[O:29]1[C:33]2([CH2:38][CH2:37][NH:36][CH2:35][CH2:34]2)[O:32][CH2:31][CH2:30]1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[C:20]([C:17]1[CH:16]=[CH:15][C:14]([CH:12]([CH3:13])[CH2:11][N:36]2[CH2:37][CH2:38][C:33]3([O:32][CH2:31][CH2:30][O:29]3)[CH2:34][CH2:35]2)=[CH:19][CH:18]=1)(=[O:27])[C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 674351,4-Dioxa-8-azaspiro(4.5)decaneHCID 12802913HCID 12802913, compound

Product 1

HCID 12805107HCID 12805107, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Reaction of the 2-(4-benzoylphenyl)propyl p-toluenesulfonate described above with 1,4-dioxa-8-azaspiro[4,5]decane in DMF in the presence of anhydrous potassium carbonate affords 8-[2-(4-benzoylphenyl)propyl]-1,4-dioxa-8-azaspiro[4,5]decane.

Sources & evidence

ORD record
ord-d76222cac733428485c120b5138b8f52
Source dataset
uspto-grants-1980_08
Patent number
US04216326

Reaction notes

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