Maleic Anhydride → HCID 178456689, compound

HRID 1856452Notes

Reaction equation

HRID 1856452 reaction equation
[C:1]1(=[O:7])O[C:4](=[O:5])[CH:3]=[CH:2]1.S(O)(O)(=O)=O.[CH:13]([NH:16][NH2:17])([CH3:15])[CH3:14]>O.Cl>[CH:13]([N:16]1[C:4](=[O:5])[CH:3]=[CH:2][C:1]([OH:7])=[N:17]1)([CH3:15])[CH3:14]

Participants

5

Reactant 2

HCID 7923Maleic AnhydrideHCID 3017832Sulfuric acid--(propan-2-yl)hydrazine (1/1)

Product 1

HCID 178456689HCID 178456689, compoundYield 64%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 962WaterSolvent

Conditions

Temperature
0 °C

Procedure

The following example illustrates the preparation of the novel compounds: ##STR6## 58.8 g (0.6 mol) of maleic anhydride were added to a solution of 73.8 g (0.6 mol) of isopropylhydrazine sulphate in 180 ml of water and 10 ml of concentrated hydrochloric acid at 60° C. The mixture was then boiled for 3 hours under reflux after which it was cooled to 0° C. After half an hour, the product which had precipitated was filtered off. 59 g (64% of theory) of 1-isopropyl-1,6-dihydro-3-hydroxy-6-oxo-pyridazine were thus obtained in the form of colorless crystals of melting point 148° C.

Workup

  1. customthe preparation of the novel compounds
  2. temperatureunder reflux after which it
  3. waitAfter half an hour
  4. customthe product which had precipitated
  5. filtrationwas filtered off

Sources & evidence

ORD record
ord-7f33cc590a2a4d12a64df81c6faf0140
Source dataset
uspto-grants-1980_08
Patent number
US04219546

Reaction notes

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