HCID 23345025, compound → 1-Phenylpiperazine

HRID 1856457Notes

Reaction equation

HRID 1856457 reaction equation
[OH:1][CH:2]([CH2:19][N:20]1[CH2:25][CH2:24][N:23]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:22][CH2:21]1)[CH2:3][O:4][C:5]1[CH:6]=[C:7]([CH:13]2[NH:17][C:16](=[O:18])[CH2:15][CH2:14]2)[CH:8]=[CH:9][C:10]=1[O:11][CH3:12]>C(O)C>[O:1]1[CH2:19][CH:2]1[CH2:3][O:4][C:5]1[CH:6]=[C:7]([CH:13]2[NH:17][C:16](=[O:18])[CH2:15][CH2:14]2)[CH:8]=[CH:9][C:10]=1[O:11][CH3:12].[C:26]1([N:23]2[CH2:24][CH2:25][NH:20][CH2:21][CH2:22]2)[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

Participants

4

Reactant 1

HCID 23345025HCID 23345025, compound

Product 2

HCID 70961-PhenylpiperazineYield 95%HCID 23345035HCID 23345035, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

From 10 mmol of 5-[3-(2,3-epoxypropoxy)-4-methoxyphenyl]-2-pyrrolidone and 10 mmol of 1-phenylpiperazine (95% strength), 5-{3-[2-hydroxy-3-(4-phenylpiperazin-1-yl)propoxy]-4-methoxyphenyl }-2-pyrrolidone, m.p. 127°-131° (ethanol) is obtained in 52% yield, analogously to the process of Example 1.

Sources & evidence

ORD record
ord-419731da5d3347d692883777be308d75
Source dataset
uspto-grants-1980_08
Patent number
US04219551

Reaction notes

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