Ethanol → HCID 23345040, compound

HRID 1856461Notes

Reaction equation

HRID 1856461 reaction equation
Br[CH:2]([CH3:20])[CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]([CH:14]2[CH2:18][NH:17][C:16](=[O:19])[CH2:15]2)[CH:9]=[CH:10][C:11]=1[O:12][CH3:13].[C:21]1([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.C(O)C>CO.C(Cl)(Cl)Cl>[CH3:13][O:12][C:11]1[CH:10]=[CH:9][C:8]([CH:14]2[CH2:18][NH:17][C:16](=[O:19])[CH2:15]2)=[CH:7][C:6]=1[O:5][CH2:4][CH2:3][CH:2]([CH3:20])[N:30]1[CH2:31][CH2:32][N:27]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:28][CH2:29]1

Participants

5

Reactant 3

HCID 702EthanolHCID 70961-PhenylpiperazineHCID 23345027HCID 23345027, compound

Product 1

HCID 23345040HCID 23345040, compoundYield 19.8%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

Analogously to Example 7, using 10 mmol of 4-[3-(3-bromobutoxy)-4-methoxyphenyl]-2-pyrrolidone and 11 mmol of 1-phenylpiperazine (95% strength), 4-{4-methoxy-3-[3-methyl-3-(4-phenylpiperazin-1-yl)propoxy]phenyl}-2-pyrrolidone is obtained in a 19.8% yield, m.p. 88°-90° (ethanol; after chromatography methanol/chloroform 1:9).

Sources & evidence

ORD record
ord-622da1d2afda40a180ac280008ad7ef7
Source dataset
uspto-grants-1980_08
Patent number
US04219551

Reaction notes

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